Welcome Laureates PhD call 2021
We warmly welcome to our community the laureates of the Bordeaux Neurocampus Graduate Program doctoral contracts 2021.
Name: Elena BAZ BADILLO
Thesis: Combining electrophysiology, live-imaging and transcriptomic at the single cell level to decode brain wiring
Motivation: Over the years, I have grown an interest in neurodevelopment; specifically, how are central circuits arranged and stabilised depending on both neuronal activity and gene expression. This project gathers all these interests, plus a cutting-edge, multidisciplinary approach at single-cell level to explore this question. For my PhD thesis, I will use patch-seq, live-imaging and optogenetics to understand how individual neurons chose their partners in the olivocerebellar system during postnatal development, as well as the role of Cell Adhesion Molecules expression in this process. I will work in a team offering all the needed expertise and promoting collaboration with other Bordeaux Neurocampus teams.
Supervisor: Mathieu LETELLIER
Team: Molecules of Cell Adherence in Synaptic Assembly
Name : Thibault DHELLEMMES
Nationality : French
Thesis: Peptidergic control of pain and emotion: morpho-functional plasticity of the Relaxine-3/RXFP3 system in the cingulate cortex of a mouse model of chronic
Motivation: In the past few years, I have become passionate about brain imaging and neurological disorders, and my objective during my academic cursus always has been to learn more about neuroscience. Above all, chronic pain research is a subject very close to my heart. Introduced to the pain-related Relaxine3/RXFP3 system in Team Landry during my Bachelor’s, I have since then seek to pursue this study. In this way, during my Master’s, I got trained in CLEM (Correlative Light-Electron Microscopy) and I had the opportunity to test and adapt this approach for the study of Relaxin3 microcircuits. I also had the chance to do microendoscopic calcium imaging in freely moving animals to observe the functional features of this system. Thus, my role in this thesis project with Pr. Marc Landry will be to use the techniques previously exposed to study the plasticity of ACC’s (anterior cingulate cortex) Relaxine3/RXFP3 microcircuits in chronic pain conditions.
Supervisor: Marc Landry
Team: Neuronal circuits of associative learning
Name : Cloé L'HERAUX
Thesisthe role of chandelier interneurons in fear circuits, within the team Neural circuits of associative learning
Motivation: My strongest interest in neuroscience is dedicated to neuronal circuits underlying memory and emotions, thus, this team certainly fits my aspiration. Aiming at unravelling the role of chandelier interneurons in fear circuits, this project is in continuity with my master thesis. Intrigued by those interneurons for which selective manipulation was hitherto impossible, I am enthusiastic to understand their role in PFC circuitry, known for its role in fear memory. This project will enable to expand my knowledge in networks physiology and fear memory while my newly acquired expertise on in vivo electrophysiology and behavioural assays could be an asset.
Supervisor: Thomas BIENVENU
Team: Purinergic signalling, inflammation and neurological disorders
Name : Hadrien PLAT
Thesis: Learning to decide: a neurocognitive perspective in rats
Motivation: Throughout my training first in biology and then in neuroscience, I have acquired the required theoretical knowledge and methodological skills to succeed in a challenging program. As attested by my records and reference letters, my scientific interests are strongly rooted into the understanding of the neural systems underlying adaptive decision making. As a result, I am looking forward to work with the Neurobiology of executive functions team at the Neurocampus.
Supervisor: Etienne COUTUREAU
Team : Neurobiology of executive functions
Name : Jasmine Jade BUTLER
Nationality : Australian
Thesis: Différences interindividuelles, monoamines, et neuropharmacologie des troubles de l'humeur
Motivation: The practical component of my master focused extensively on the monoaminergic system, initially under the supervision of Prof Dr Phillipe De Deurwaerdere and subsequently Dr Timothy Zolnik, developing a code for quantitative and corelative analysis of monoaminergic differences, and mechanism of action for the antidepressant properties of psychedelics respectively. Each project particularly considering the serotonergic system, the current target for antidepressants and of classical psychedelics currently in clinical trials. I believe that this experience will provide an ideal background for further research into mood disorders, interindividual variability and 5-HT2A agonist as antidepressants. As alumnus of the university, I feel confident that this environment will facilitate my growth academically and specifically this project in a direction I find fascinating.
Supervisor: Philippe DE DEURWAERDERE
Team : Coordination and plasticity of spinal generators
Linkedin : https://www.linkedin.com/in/jasmine-butler-589bb7118/